MethylMax™ is a full-spectrum methylation formula for the support of all major methylation pathways. Methylmax is commonly recommended for patients with an elevated norepinephrine/epinephrine ratio as well as for patients who exhibit decreased stamina and/or low energy.


Methylation is important for:

  • Detoxification of heavy metals
  • Regulation of gene expression
  • DNA repair
  • Regulation of protein function
  • Synthesis/metabolism of some neurotransmitters
  • Maintaining healthy homocysteine levels

SAMe plays roles in:

  • Phospholipid synthesis
  • Low mood
  • Connective tissue health
  • Healthy liver function
  • Attention


How It Works

Methylation plays a vital role in systems throughout the body including : detoxification of heavy metals, regulation of gene expression, DNA repair, regulation of protein function, and synthesis/metabolism of some neurotransmitters. One of the important biochemical pathways methylation is intimately involved with is the homocysteine/methionine cycle. Homocysteine levels impact cardiovascular health.

MethylMax contains multiple ingredients that support methylation and a healthy homocysteine/methionine cycle. B vitamins (B6, B9, and B12) help maintain healthy homocysteine metabolism. Trimethylglycine (TMG) or betaine and SAMe are methyl donors in the homocysteine cycle. In fact, TMG methylates homocysteine ultimately generating SAMe.

SAMe is the primary methyl donor in the brain. It is a required cofactor in the conversion of norepinephrine to epinephrine and serotonin to melatonin. Additionally, SAMe is a cofactor for the enzyme catechol-o-methyltransferase, which breaks down catecholamine neurotransmitters.

MethylMax may be recommended in conjunction with other TNT products such as Prolent™ and Procite-D™ to support healthy neurotransmitter levels. Given the importance of methylation, MethylMax may be recommended in Initial, Restoration, and Maintenance phases along the path to wellness.

Explanation of Ingredients

Vitamin B6 (as pyridoxal-5’-phosphate) Active form of B6. Cofactor in the methylfolate cycle and metabolism of homocysteine.

Folate (as (6S)-5-methyl-tetrahydro folic acid, glucosamine salt) (Quatrefolic®) Active form of B9. Methyl group donor.

Cofactor in methylation reactions essential for the synthesis of dopamine, norepinephrine and epinephrine and break down of homocysteine.

Vitamin B12 (as Methylcobalamin) Coenzyme form of Vitamin B12. Methyl donor. Supports homocysteine metabolism.

SAMe (s-adenosyl-l-methionine)(as Adomix®) Activated form of a sulfur-containing essential amino acid. Primary methyl donor in the brain Adomix is a room temperature stable form of SAMe.

Betaine (Trimethylglycine) Amino acid that functions as a methyl donor.* Supports SAMe production/recycling.

Supplement Facts

Serving Size: 2 Capsules
Servings Per Container: 30

Methylation™ Formula  420.98 mg
Vitamin B6 (as pyridoxal-5-phosphate)
Folate (as (6S)-5-methyl-tetrahydro folic acid, glucosamine salt) (Quatrefolic®)
Vitamin B12 (as methylcobalamin)
Calcium (as dicalcium phosphate)
SAMe (s-adenosyl-l-methionine)(as Adomix®)
Betaine (Trimethylglycine)


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